A three-dimensional morpho-volumetric similarity study of Down syndrome keratopathy vs. keratoconus

Autor: Ibrahim Toprak, Francisco Cavas, José S. Velázquez, Jorge L. Alio del Barrio, Jorge L. Alio
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Eye and Vision, Vol 10, Iss 1, Pp 1-7 (2023)
Druh dokumentu: article
ISSN: 2326-0254
DOI: 10.1186/s40662-022-00315-0
Popis: Abstract Background To compare and contrast morpho-volumetric features between Down syndrome (DS) cornea and non-DS keratoconic cornea by three-dimensional (3D) modelling. Methods Forty-three subjects (43 eyes) with DS and 99 patients matching their age and sex (99 eyes) with keratoconus (KC) were included in this single-center cross-sectional study. Main outcome measures were high-order aberrations (HOA), central corneal thickness (CCT), spherical equivalent refraction, and morpho-volumetric parameters established using a 3D corneal model, such as deviation of anterior and posterior corneal apices (Dapexant/Dapexpost) and minimum thickness points (Dmctant/Dmctpost) from corneal vertex, areas of the anterior and posterior surfaces (Aant/Apost), sagittal area passing through the anterior and posterior corneal apices (Aapexant/Aapexpost) and minimum thickness point (Amctpost) and corneal volume of the complete cornea (Vtotal). Results Age, gender, spherical equivalent refraction, CCT and Vtotal were similar between the net on-DS KC and DS groups (P > 0.05), while non-DS KC group had higher HOA than the DS group (P
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