Clinical Investigation of French Maritime Pine Bark Extract on Attention-Deficit Hyperactivity Disorder as compared to Methylphenidate and Placebo: Part 2: Oxidative Stress and Immunological Modulation

Autor: Anne-Sophie Weyns, Annelies A.J. Verlaet, Maxim Van Herreweghe, Annelies Breynaert, Erik Fransen, Ingrid De Meester, Emilie Logie, Wim Vanden Berghe, Helene Verhelst, Dirk Van West, Ingrid Van Ingelghem, An I. Jonckheere, Diane Beysen, Sandra Kenis, Els Moens, Aalt P.J. van Roest, Huub F.J. Savelkoul, Tess De Bruyne, Luc Pieters, Berten Ceulemans, Nina Hermans
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Functional Foods, Vol 97, Iss , Pp 105247- (2022)
Druh dokumentu: article
ISSN: 1756-4646
DOI: 10.1016/j.jff.2022.105247
Popis: Objectives: To evaluate the effect of French Maritime Pine Bark Extract (PBE; Pycnogenol®) on immune, oxidative stress and neurochemical biomarkers in paediatric Attention-Deficit Hyperactivity Disorder (ADHD) as compared to methylphenidate (MPH) and placebo. Results: Paediatric ADHD patients (n = 88, 70 % male, mean age 10.1 years) were randomised (placebo (n = 30), PBE (n = 32) and MPH (n = 26)) receiving 20 mg/day if
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