Activatable theranostic prodrug scaffold with tunable drug release rate for sequential photodynamic and chemotherapy

Autor: Si‐Yu Wang, Ying‐Hao Pan, Yu‐Chen Qu, Xiao‐Xiao Chen, Na Shao, Li‐Ya Niu, Qing‐Zheng Yang
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Smart Molecules, Vol 2, Iss 1, Pp n/a-n/a (2024)
Druh dokumentu: article
ISSN: 2751-4595
2751-4587
DOI: 10.1002/smo.20230024
Popis: Abstract Glutathione (GSH)‐activated prodrugs are promising for overcoming the limitations of conventional anti‐tumor drugs. However, current GSH‐responsive disulfide groups exhibit unregulated reactivity, making it impossible to precisely control the drug release rate. We herein report a series of GSH‐responsive prodrugs with a “three‐in‐one” molecular design by integrating a fluorescence report unit, stimuli‐responsive unit and chemodrug into one scaffold with tunable aromatic nucleophilic substitution (SNAr) reactivity. The drug release rate of these prodrugs is tailored by modification of substituent groups with different electron‐withdrawing or ‐donating abilities on the BODIPY core. Furthermore, the prodrugs self‐assemble in water to form nanoparticles that serve as photosensitizers to produce reactive oxygen species upon irradiation for photodynamic therapy (PDT). The PDT process also increases the concentration of GSH in cells, further promoting the release of drugs for chemotherapy. This strategy provides a powerful platform for sequential photodynamic and chemotherapy with tunable drug release rates and synergistic therapeutic effects.
Databáze: Directory of Open Access Journals
Externí odkaz: