| Autor: |
Qiaozhi Wei, Sandra Pinho, Shuxian Dong, Halley Pierce, Huihui Li, Fumio Nakahara, Jianing Xu, Chunliang Xu, Philip E. Boulais, Dachuan Zhang, Maria Maryanovich, Ana Maria Cuervo, Paul S. Frenette |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-021-22749-1 |
| Popis: |
Haematopoietic stem cells (HSCs) are metabolically quiescent, with balanced myeloid and lymphoid potential. Here the authors show that MAEA is required in HSCs for ubiquitination and downregulation of surface cytokine receptors via autophagy; MAEA loss leads to impaired HSC quiescence and a myeloproliferative disorder. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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