Black pepper extract reduces tumour incidence via suppressing tumour-promoted cytokines/chemokines and modulating T cell subtype
| Autor: | Nadeeya Mad-adam, Sirinapa Dokduang, Siriporn Taraporn, Thidarath Rattanaburee, Jirakrit Saetang, Aekkaraj Nualla-ong, Somchai Sriwiriyajan, Jasadee Kaewsrichan, Yaowapa Sukpondma, Poonsit Hiransai, Potchanapond Graidist |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Food and Agricultural Immunology, Vol 35, Iss 1 (2024) |
| Druh dokumentu: | article |
| ISSN: | 09540105 1465-3443 0954-0105 |
| DOI: | 10.1080/09540105.2024.2408282 |
| Popis: | Our study aimed to evaluate tumour retardation effects of low-piperine fractional Piper nigrum extract (PFPE or LP-PE) related to enhancement of immune response. Results showed that PFPE at doses of 50 (low), 100 (intermediated) and 150 (high) mg/kg BW had a tumour incidence of 20, 20 and 0%, respectively. PFPE at low dose inhibited cytokines/chemokines in the early stages of cancer however it could not suppress longer than 3 months. Intermediated dose of PFPE inhibited cancer cytokines/chemokines including sICAM-1, CX3CL1, CXCL7, VEGF, TIMP-1, CCL5, CCL20, CXCL1, CXCL5, CXCL9 and IL-1β. Interestingly, PFPE stimulated IFN- γ at 3 months after treatment in all doses. Intermediated and high doses of PFPE increased Th1 and reduced Th2. Moreover, only a high dose of PFPE reduced Treg. Additionally, PFPE reduced ER-α and NF-κB and increased IL-6R and STAT3 proteins in tumour tissues. Our findings indicate that PFPE suppressed breast cancer via immune modulation. |
| Databáze: | Directory of Open Access Journals |
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