| Autor: |
Hensel Nancy, Li Jongming, Melenhorst Jos, Rezvani Katayoun, Provenzano Maurizio, Sconocchia Giuseppe, Barrett A John |
| Jazyk: |
angličtina |
| Rok vydání: |
2005 |
| Předmět: |
|
| Zdroj: |
Journal of Translational Medicine, Vol 3, Iss 1, p 15 (2005) |
| Druh dokumentu: |
article |
| ISSN: |
1479-5876 |
| DOI: |
10.1186/1479-5876-3-15 |
| Popis: |
Abstract In vitro stimulation of CD34+ cells with IL-2 induces NK cell differentiation. In order to define the stages of NK cell development, which influence their generation from CD34 cells, we cultured G-CSF mobilized peripheral blood CD34+ cells in the presence of stem cell factor and IL-2. After three weeks culture we found a diversity of CD56+ subsets which possessed granzyme A, but lacked the cytotoxic apparatus required for classical NK-like cytotoxicity. However, these CD56+ cells had the unusual property of inhibiting proliferation of K562 and P815 cell lines in a cell-contact dependent fashion. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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