Statistical Design of Sustained-Release Tablet Garcinia cambogia Extract and Bioconverted Mulberry Leaf Extract for Anti-Obesity

Autor: Hye-Jin Lee, Young-Guk Na, Mingu Han, Thi Mai Anh Pham, Hyeonmin Lee, Hong-Ki Lee, Chang-Seon Myung, Joo-Hui Han, Jong-Seong Kang, Kyung-Tae Kim, Cheong-Weon Cho
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Pharmaceutics, Vol 12, Iss 10, p 932 (2020)
Druh dokumentu: article
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics12100932
Popis: Obesity is a major health concern worldwide, and it is leading to worsening disease morbidity and mortality. Herbal supplements and diet-based therapies have attracted interest in the treatment of obesity. It is known that Garcinia cambogia (GA) and mulberry leaf, which contain polyphenols, have anti-obesity activity. Herein, we developed a combined tablet consisting of GA extract and bioconverted mulberry leaf extract (BMUL) using a statistical design approach. The ratio and amount of sustained polymers were set as factors. In the cell study, the combination of GA and BMUL showed synergistic anti-obesity activity. In a statistical model, the optimized amounts of hydroxypropyl methylcellulose 2208 (HPMC 2208) and polyethylene oxide 303 (POLYOX 303) were 41.02% and 58.98%, respectively. Additionally, the selected ratio of microcrystalline cellulose (MCC) was 0.33. When the release, hardness, and friability of the GABMUL tablet were evaluated, the error percentages of the response were lower than 10%. This indicates that the GABMUL tablet was successfully prepared.
Databáze: Directory of Open Access Journals
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