The co-treatment of rosuvastatin with dapagliflozin synergistically inhibited apoptosis via activating the PI3K/AKt/mTOR signaling pathway in myocardial ischemia/reperfusion injury rats

Autor: Gong Lei, Wang Xuyang, Pan Jinyu, Zhang Mingjun, Liu Dian, Liu Ming, Li Li, An Fengshuang
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Open Medicine, Vol 16, Iss 1, Pp 047-057 (2020)
Druh dokumentu: article
ISSN: 2391-5463
DOI: 10.1515/med-2021-0005
Popis: The purpose of the present study was to evaluate the role of co-treatment of rosuvastatin (RSV) and dapagliflozin (DGZ) preconditioning in myocardium ischemia/reperfusion (I/R) injury and to further investigate the underlying mechanism.
Databáze: Directory of Open Access Journals