Effect of chlorpyrifos on the level of hippocampal caspase 9 in male rats: Short Commuincation
| Autor: | Sina Nikbin, Armin Derakhshideh, Mohammad Ali Azarbayjani, Nasrin Hosseini |
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| Jazyk: | perština |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | مجله دانشگاه علوم پزشکی بیرجند, Vol 30, Iss 2, Pp 189-195 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1607-2197 2423-6152 |
| Popis: | Chlorpyrifos (CPF) is an organophosphate pesticide that can damage the nervous system of insects by causing neurotoxicity. Although the molecular mechanisms related to it are not fully understood, some studies have suggested that apoptotic processes are involved. Caspase 9 is a protease that is related to the process of mitochondrial death and is activated during apoptosis. Therefore, the present study aimed to investigate the effect of CPF exposure on Caspase 9 level in the hippocampus of rats. In this experimental study, 24 male Wistar rats (180-220 g) were randomly divided into four groups, including control, sham, CPF 1mg/kg.bw, and CPF 3mg/kg.bw (n=6). Data analysis was performed using one-way ANOVA and post hoc Tucky statistical tests. The findings pointed to significant differences between control and CPF-1mg (P |
| Databáze: | Directory of Open Access Journals |
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