RHEUMATOID ARTHRITIS WITH SYSTEMIC MANIFESTATIONS: DIAGNOSIS, INDICATORS OF AN UNFAVORABLE COURSE
| Autor: | B D Nazarov, Yor Umarovich Saidov, D A Khalilova, R N Zubaidov, B R Shodiyev |
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| Jazyk: | ruština |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Научно-практическая ревматология, Vol 50, Iss 6, Pp 45-49 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1995-4484 1995-4492 |
| DOI: | 10.14412/1995-4484-2012-1293 |
| Popis: | The systemic manifestations of rheumatoid arthritis (RA) are fairly diverse. They are associated with high disease activity and an increased risk for deaths, primarily from cardiovascular events. Objective: to study the frequency and spectrum of extra-articular manifestations of RA. Subjects and methods. The trial enrolled 119 patients, including 110 women and 19 men (mean age 47.4+4.3 years), with the reliable and valid diagnosis of RA (mean duration 9.4+3.3 years). The patients were divided into 2 groups: 1) 78 patients with the extra-articular manifestations of RA (a study group); 2) 44 patients without these signs (a comparison group). Clinical, laboratory, instrumental, and morphological studies were made using current diagnostic methods. Results. By and large, the extra-articular manifestations of RA are closely associated with its activity and joint lesion severity. The study group most commonly had anemia (71.4%), rheumatoid nodules (29.4%), generalized amyotrophy (26.9%), lymphadenopathy (26.1%), prolonged fever (24.4%), and rheumatoid vasculitis (18.5%). The development of extra-articular manifestations was associated with the activity and late diagnosis of RA and rheumatoid factor seropositivity. |
| Databáze: | Directory of Open Access Journals |
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