Effect of palmatine hydrochloride on cognitive dysfunction in streptozotocin-induced diabetic Rats
| Autor: | Ahouei M, Vaezi Gh, Kalalian Moghaddam H, Alamalhoda F |
|---|---|
| Jazyk: | perština |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | مجله دانشگاه علوم پزشکی گرگان, Vol 15, Iss 1, Pp 38-44 (2013) |
| Druh dokumentu: | article |
| ISSN: | 1562-4765 2008-4080 |
| Popis: | Background and Objective: Recent studies have shown that diabetes induced cognitive dysfunction and impairs learning and memory. Palmatine is an isoquinoline alkaloid, and has multiple pharmacological effects, including anti-diabetic and antioxidant activity. This study was conducted, to evaluate the effect of Palmatine on learning and spatial memory impairment in STZ-induced diabetic rats. Materials and Methods: This experimental study was conducted on the male Wistar rats (n=32) with approximate weight of 240±40 grams. The rats were randomly allocated and were divided into 4 groups (n=8): Control, Palmatine-treated non-diabetic, diabetic and Palmatine-treated diabetic groups. Diabetes was induced by STZ administration at the dose of 55 mg/kg through intraperitoneal route. Palmatine hydrochloride was administered subcutaneous at doses of 10 mg/kg/day 1 week after STZ injection for a period of 6 weeks. Blood samples were taken from the tail vein 1, 3, 5, 7 weeks after STZ injection to measure blood glucose levels. Behavioral tests including spatial recognition and objective recognition were performed at the end of study. Data were analyzed by using Prism-5, one way ANOVA and Tukey tests. Results: In spatial recognition test, the number of entrance in new arm of the Ymaze, in the Palmatine-treated groups significantly increased in compare to diabetic group in both sixth and seventh weeks (P |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|