Effect of Qingkailing injection on platelets function preserved in vitro
| Autor: | Jie LI, Xuerui ZHANG, Wenbin FENG, Yan HUANG, Jun WANG, Yunlong WANG, Xiaoxia TAN, Jiongcai LAN |
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| Jazyk: | čínština |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Zhongguo shuxue zazhi, Vol 35, Iss 4, Pp 387-391 (2022) |
| Druh dokumentu: | article |
| ISSN: | 1004-549X 1004-549x |
| DOI: | 10.13303/j.cjbt.issn.1004-549x.2022.04.008&lang=en |
| Popis: | Objective To investigate the effect of Qingkailing injection on platelet function preserved in vitro. Methods A total of 15 bags of plateletpheresis (≥250 mL/bag), adding Qingkailing injection(1.25 mL/bag) at the final concentration of 1%, were stored at 22 ℃ with gentle agitation as the experimental group, and samples were collected on day 1, 3, 5, 8, 10 and 14 to detect the thromboelastogram (TEG), CD62p expression rate and mitochondrial membrane potential (JC-1). The control group was set up synchronously, with the same volume and storage conditions as the experimental groups, and samples were taken on day 1, 3 and 5 after preservation to undertake the same test items as the experimental groups. The differences of detection indexes between the two groups were compared. Results 1) In the experimental group, there was no significant change in K and α during day 1 to 14(P>0.05). The R value (min) increased from 6.12±1.58 to 11.02±2.26, and the CI value changed from 0.27±1.24 to -10.47±3.51 (P0.05), but decreased to 53.18±2.71 on day 8 and 22.88±3.45 on day 14 (P0.05), but JC-1 (%) was 86.75±3.88 vs 70.36±19.8 on day 5 (P |
| Databáze: | Directory of Open Access Journals |
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