Quantitative imaging of magnetic nanoparticles in an unshielded environment using a large AC susceptibility array

Autor: Guilherme Soares, Leonardo Pinto, Maik Liebl, Gabriel Biasotti, Andre Prospero, Erick Stoppa, Andris Bakuzis, Oswaldo Baffa, Frank Wiekhorst, José Ricardo Arruda Miranda
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Biological Engineering, Vol 16, Iss 1, Pp 1-11 (2022)
Druh dokumentu: article
ISSN: 1754-1611
DOI: 10.1186/s13036-022-00305-9
Popis: Abstract Background Non-invasive magnetic imaging techniques are necessary to assist magnetic nanoparticles in biomedical applications, mainly detecting their distribution inside the body. In Alternating Current Biosusceptometry (ACB), the magnetic nanoparticle's magnetization response under an oscillating magnetic field, which is applied through an excitation coil, is detected with a balanced detection coil system. Results We built a Multi-Channel ACB system (MC-ACB) containing nineteen pick-up coils and obtained 2D quantitative images of magnetic nanoparticle distributions by solving an inverse problem. We reconstructed the magnetic nanoparticles spatial distributions in a field of view of 14 × 14 cm2 with a spatial resolution of 2.0 cm and sensitivity in the milligram scale. A correlation coefficient between quantitative reconstructed and nominal magnetic nanoparticle distributions above 0.6 was found for all measurements. Conclusion Besides other interesting features such as sufficient large field of view dimension for mice and rat studies, portability, and the ability to assess the quantitative magnetic nanoparticles distributions in real-time, the MC-ACB system is a promising tool for quantitative imaging of magnetic nanoparticles distributions in real-time, offering an affordable setup for easy access in clinical or laboratory environments.
Databáze: Directory of Open Access Journals
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