Development of a Conceptual Model of the Patient Experience in Small Cell Lung Cancer: A Qualitative Interview Study

Autor: Danielle E. Altman, Xinke Zhang, An-Chen Fu, Alissa R. Rams, Jessica A. Baldasaro, Samir Ali Ahmad, Michael Schlichting, Patrick Marquis, Elena Benincasa, Camilo Moulin, Vivek Pawar
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Oncology and Therapy, Vol 11, Iss 2, Pp 231-244 (2023)
Druh dokumentu: article
ISSN: 2366-1070
2366-1089
DOI: 10.1007/s40487-023-00223-w
Popis: Abstract Introduction Small cell lung cancer (SCLC) is a subtype of lung cancer, the second most common cancer diagnosis worldwide. Currently, there is little published qualitative research that provides insight into the disease-related symptoms and impacts that are relevant to patients living with SCLC as directly reported by patients themselves. Methods This qualitative, cross-sectional, noninterventional, descriptive study included concept elicitation interviews with participants diagnosed with SCLC and the development of a conceptual model of clinical treatment benefit. Results Concept elicitation interview data from 26 participants with SCLC were used to develop a conceptual model of clinical treatment benefit that organized 28 patient-reported concepts into two domains: disease-related symptoms (organ-specific and systemic) and impacts. Organ-specific symptoms included cough, chest pain, and difficulty breathing. Systemic symptoms included pain, fatigue, appetite loss, and dizziness. Impacts included physical functioning, role functioning, reduced movement, impact on sleep, and weight loss. Conclusion As evidenced by this study, people with SCLC experience considerable and significant symptoms and impacts, including physical and role functioning challenges, that affect their quality of life. This conceptual model will inform the design of a patient-reported outcome (PRO) questionnaire for a future SCLC clinical trial, helping to establish the content validity of the items and questionnaires used in the trial and ensuring that the questionnaires and items selected are appropriately targeted to the population. This conceptual model could also be used to inform future SCLC clinical trials.
Databáze: Directory of Open Access Journals
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