| Autor: |
Masthan Basha Shaik, Divya Vurundhur, Kiran Kumar Mallam, Mohammad Gulabi |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Journal of Research in Applied and Basic Medical Sciences, Vol 10, Iss 1, Pp 80-87 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2717-0098 |
| Popis: |
Background & Aims: Platelet-rich plasma (PRP) has emerged as a treatment for osteoarthritis (OA) and rheumatoid arthritis (RA). The aim of the current study is to assess the effect of PRP injection and its influence on interleukin-6 (IL-6) in the synovial fluid of the knee joint in OA and RA patients. Materials & Methods: Clinico-radiologically diagnosed case of OA and RA of 30 each was included during the study period of 2 years. 10 ml of patient blood collected and PRP was prepared by differential centrifugation method, and this freshly prepared PRP was injected to the affected knee joint slowly. IL-6 levels assessed in synovial fluid at pre-PRP injection and 1st, 3rd and 6th month post-PRP Injection. Pain was measured using Visual Analog Scale. Results: The mean age of the cases was 58.5 years for OA and 47.2 years for RA. Females were predominantly compared to males. Majority were Kellegren Lawrence radiological grade 3 in 15 (50%) cases, following grade 2 in 8 (26.67%) cases, grade 4 in 6(20%) cases and grade 1 in 1(3.33%) case. Mean IL-6 in OA cases was 89.5±24.5 pg/ml at pre PRP, and 66.48±23.1 pg/ml at post PRP (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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