Hepatocellular Carcinoma: The Role of MicroRNAs

Autor:	Sharad Khare, Tripti Khare, Raghu Ramanathan, Jamal A. Ibdah
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	hepatocellular carcinoma microRNA metastasis heterogeneity therapeutics Microbiology QR1-502
Zdroj:	Biomolecules, Vol 12, Iss 5, p 645 (2022)
Druh dokumentu:	article
ISSN:	2218-273X
DOI:	10.3390/biom12050645
Popis:	Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. HCC is diagnosed in its advanced stage when limited treatment options are available. Substantial morphologic, genetic and epigenetic heterogeneity has been reported in HCC, which poses a challenge for the development of a targeted therapy. In this review, we discuss the role and involvement of several microRNAs (miRs) in the heterogeneity and metastasis of hepatocellular carcinoma with a special emphasis on their possible role as a diagnostic and prognostic tool in the risk prediction, early detection, and treatment of hepatocellular carcinoma.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/05272bcf6fde430fa2826b9eab08ba97 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.