Waterborne Elizabethkingia meningoseptica in Adult Critical Care

Autor: Luke S.P. Moore, Daniel S. Owens, Annette Jepson, Jane F. Turton, Simon Ashworth, Hugo Donaldson, Alison H. Holmes
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Emerging Infectious Diseases, Vol 22, Iss 1, Pp 9-17 (2016)
Druh dokumentu: article
ISSN: 1080-6040
1080-6059
DOI: 10.3201/eid2201.150139
Popis: Elizabethkingia meningoseptica is an infrequent colonizer of the respiratory tract; its pathogenicity is uncertain. In the context of a 22-month outbreak of E. meningoseptica acquisition affecting 30 patients in a London, UK, critical care unit (3% attack rate) we derived a measure of attributable morbidity and determined whether E. meningoseptica is an emerging nosocomial pathogen. We found monomicrobial E. meningoseptica acquisition (n = 13) to have an attributable morbidity rate of 54% (systemic inflammatory response syndrome >2, rising C-reactive protein, new radiographic changes), suggesting that E. meningoseptica is a pathogen. Epidemiologic and molecular evidence showed acquisition was water-source–associated in critical care but identified numerous other E. meningoseptica strains, indicating more widespread distribution than previously considered. Analysis of changes in gram-negative speciation rates across a wider London hospital network suggests this outbreak, and possibly other recently reported outbreaks, might reflect improved diagnostics and that E. meningoseptica thus is a pseudo-emerging pathogen.
Databáze: Directory of Open Access Journals
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