Data on synthesis, ADME and pharmacological properties and early safety pharmacology evaluation of a series of novel NURR1/NOT agonist potentially useful for the treatment of Parkinson's disease

Autor: André Malanda, Pierre-Yves Abécassis, Pascal Barnéoud, Pascale Brunel, Véronique Taupin, Xavier Vigé, Dominique Lesuisse
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Data in Brief, Vol 27, Iss , Pp - (2019)
Druh dokumentu: article
ISSN: 2352-3409
DOI: 10.1016/j.dib.2019.104057
Popis: This article describes the chemical synthesis, ADME and pharmacological properties and early safety pharmacology evaluation of a series of novel Nurr1/NOT agonist. It is meant as a support to an article recently published in Bioorganic and Medicinal chemistry Letters and entitled “Development of a novel NURR1/NOT agonist from hit to lead and candidate for the potential treatment of Parkinson's disease” [1] and presenting the discovery, scope and potential of these new ligands of these nuclear receptors.
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