Is neutropenic fever an obstacle to effective stem cell harvesting?
| Autor: | Semih Başcı, Ersin Bozan, Samet Yaman, Bahar Uncu Ulu, Mehmet Bakırtaş, Tuğçe Nur Yiğenoğlu, Ali Kılınç, Nurgül Özcan, Mehmet Sinan Dal, Merih Kızıl Çakar, Fevzi Altuntaş |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Asian Journal of Transfusion Science, Vol 18, Iss 1, Pp 21-26 (2022) |
| Druh dokumentu: | article |
| ISSN: | 0973-6247 1998-3565 |
| DOI: | 10.4103/ajts.ajts_152_21 |
| Popis: | INTRODUCTION: Autologous stem cell transplantation (ASCT) is a well-established consolidation treatment for many hematologic cancers which delivers prolonged survival. A subset of patients’ adequate stem cell harvest is not achievable with a solitary use of granulocyte colony-stimulating agents (G-CSF). Generally, chemomobilization is employed for patients failing G-CSF and its most feared complication febrile neutropenia (FN). MATERIALS AND METHODS: Here, we aimed to investigate the impact of the FN in chemomobilization on apheresis outcomes and engraftment. One hundred and eighty-three patients with the diagnosis of lymphoma or myeloma who underwent chemomobilization between 2015 and 2020 were included in the study. RESULTS: Forty-three patients experienced FN. All patients received G-CSF. All myeloma patients were mobilized with 4 g/m2 cyclophosphamide, but it was heterogeneous for lymphoma patients. The precollection blood counts, harvested CD34+ hematopoietic stem cells (HSCs)/kg, apheresis count, and engraftment durations were recorded. Preapheresis leukocyte and platelet were lower in the FN group (P = 0,004 and P = 0,001). Peripheral CD34 HSCs and total harvested CD34 HSCs were similar among groups (P = 0.25 and P = 0.9). More apheresis was needed in the FN group, but it was not significant (P = 0.07). Undergoing ASCT was similar (P = 0.7); however, platelet and neutrophil engraftment durations were slower in the FN group (P = 0.05 and P = 0.001). CONCLUSION: Harvesting sufficient CD34+ HSCs from patients with FN is still feasible; however, FN treatment should begin promptly, and further apheresis sessions may be required. |
| Databáze: | Directory of Open Access Journals |
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