The Effect of Compulsory Sports Activities on Substantia Nigra Tissue and Behavioral Tests Induction Parkinsons Model with 6-Hydroxydopamine in Prenatal Stress Rats

Autor: Toraj Mohammad zamani, Ahmadreza Movahedi, Elahe Arab ameri
Jazyk: perština
Rok vydání: 2019
Předmět:
Zdroj: Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, Vol 26, Iss 6, Pp 143-155 (2019)
Druh dokumentu: article
ISSN: 1563-4728
2588-3135
Popis: Introduction: Prenatal stress causes brain alteration and prolongs effects on structure and function. Parkinson's is a progressive neurodegenerative disease And one of the factors motive Parkinson's is the Prenatal stress. Exercising activity is a good way to prevent the disease. The aim of this study was to investigate the effect of mandatory exercise on Substantia nigra tissue in Perinatal Parkinson's rats. Materials & Methods: A Laboratory research method was used. 48 Wistar male rats, half of them under prenatal stress And followed up on compulsory sports activities. Were divided into 8 groups of 6, with stress (control, sham, Parkinson, Parkinson + compulsory exercise) and without stress (control, sham, Parkinson, Parkinson + compulsory exercise). the animals received Stereotaxic Surgery after 8 weeks, Three weeks later, Parkinson's symptoms were evaluated using Apo morphine rotation test and Wire grasping. The number of substantia nigra neurons in the brain is counted using a microscope; Data were analyzed using One-Way ANOVA and Tukey's Post Test. Ethics code: IR.IAU.SRB.REC.1396 Findings: In groups with and without stress, the number of substantia nigra neurons compulsory sports group was different from that of the control group and this difference was statistically significant (P=0.0000). The average number of substantia nigra neurons compulsory sports group in both groups with and without stress difference was low, but statistically significant (P=0.014). Discussion & conclusions: The results refer to the effects of compulsive exercise on the better protection of Substantia nigra neurons and suggests that exercise can be effective as a beneficial factor in reducing the degeneration of dopaminergic neurons in Parkinson's disease. Prenatal stress also reduces the beneficial effects of exercise.
Databáze: Directory of Open Access Journals
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