Human alveolar progenitors generate dual lineage bronchioalveolar organoids

Autor: Karen Hoffmann, Benedikt Obermayer, Katja Hönzke, Diana Fatykhova, Zeynep Demir, Anna Löwa, Luiz Gustavo Teixeira Alves, Emanuel Wyler, Elena Lopez-Rodriguez, Maren Mieth, Morris Baumgardt, Judith Hoppe, Theresa C. Firsching, Mario Tönnies, Torsten T. Bauer, Stephan Eggeling, Hong-Linh Tran, Paul Schneider, Jens Neudecker, Jens C. Rückert, Achim D. Gruber, Matthias Ochs, Markus Landthaler, Dieter Beule, Norbert Suttorp, Stefan Hippenstiel, Andreas C. Hocke, Mirjana Kessler
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-022-03828-5
Popis: The GSK3 inhibitor CHIR99021 is required to maintain the alveolar lineage in alveolar progenitors grown in airway media or AT2 cells become plastic, with the observed effects acting outside of its role as a GSK3B inhibitor.
Databáze: Directory of Open Access Journals
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