An Investigation into the Role of IGF-1 and IGFBP3 in the Diagnosis and Treatment Response in Esophageal Cancer
| Autor: | Merve Müge Üçüncü, Süleyman Bademler, Murat Serilmez |
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| Jazyk: | English<br />Turkish |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi, Iss 9, Pp 852-863 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2536-4499 2602-2605 |
| DOI: | 10.38079/igusabder.586721 |
| Popis: | Aim: Esophageal cancer (EC) is the eighth most common cancer among all cancers worldwide. It constitutes 1.5-2% of all cancers and 5-7% of gastrointestinal cancers. Mortality reduction by early diagnosis, early treatment, and close follow-up is possible in esophageal cancer. However, reliable markers that rapidly provide results for early diagnosis are necessary in order to make such a diagnosis. In our study, it is aimed to investigate the role of IGFBP3 and IGF-1 in the early diagnosis of esophageal tumors. Method: 37 patients with a histopathologically confirmed diagnosis of EC and 41 age- and sex-matched healthy controls were included in our study at Istanbul University Institute of Oncology. Serum IGF-1 and IGFBP-3 levels were determined using enzyme-linked immunosorbent assay (ELISA).Findings: The mean age of the patients included in this study was 54.51±13.69 years. Based on the comparison between the groups, there was no difference in terms of gender and age (p=0.675 and 0.094). There was a statistically significant difference between the control group and the patient group in terms of IGF-1 and IGFBP3 levels. Both levels were higher in the control group (p=0.006, p |
| Databáze: | Directory of Open Access Journals |
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