Glutathione‐Responsive Nanoparticles of Camptothecin Prodrug for Cancer Therapy

Autor:	Lingpu Zhang, Lin Zhu, Lin Tang, Jiayi Xie, Yajuan Gao, Changyuan Yu, Kun Shang, Hongbin Han, Chaoyong Liu, Yunfeng Lu
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	cancer immunotherapy controlled release CPT prodrug glutathione responsive self‐assembly Science
Zdroj:	Advanced Science, Vol 10, Iss 3, Pp n/a-n/a (2023)
Druh dokumentu:	article
ISSN:	2198-3844
DOI:	10.1002/advs.202205246
Popis:	Abstract Camptothecin (CPT) is a potent chemotherapeutic agent for various cancers, but the broader application of CPT is still hindered by its poor bioavailability and systemic toxicity. Here, a prodrug that releases CPT in response to glutathione (GSH), which is commonly overexpressed by cancer cells is reported. Through assembling with PEGylated lipids, the prodrug is incorporated within as‐assembled nanoparticles, affording CPT with a prolonged half‐life in blood circulation, enhanced tumor targetingability, and improved therapeutic efficacy. Furthermore, such prodrug nanoparticles can also promote dendritic cell maturation and tumor infiltration of CD8+ T cells, providing a novel strategy to improve the therapeutic efficacy of CPT.
Databáze:	Directory of Open Access Journals
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