| Autor: |
Chen-Kai Wu, Shuai Teng, Fan Bai, Xiao-Bo Liao, Xin-Min Zhou, Qi-Ming Liu, Yi-Chao Xiao, Sheng-Hua Zhou |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Frontiers in Cardiovascular Medicine, Vol 10 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2297-055X |
| DOI: |
10.3389/fcvm.2023.1198486 |
| Popis: |
BackgroundCorrelations between posttranslational modifications and atrial fibrillation (AF) have been demonstrated in recent studies. However, it is still unclear whether and how ubiquitylated proteins relate to AF in the left atrial appendage of patients with AF and valvular heart disease.MethodsThrough LC–MS/MS analyses, we performed a study on tissues from eighteen subjects (9 with sinus rhythm and 9 with AF) who underwent cardiac valvular surgery. Specifically, we explored the ubiquitination profiles of left atrial appendage samples.ResultsIn summary, after the quantification ratios for the upregulated and downregulated ubiquitination cutoff values were set at >1.5 and |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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