| Autor: |
Timothy C. Borbet, Miranda B. Pawline, Jackie Li, Melody L. Ho, Yue Sandra Yin, Xiaozhou Zhang, Ekaterina Novikova, Katelyn Jackson, Briana J. Mullins, Victoria E. Ruiz, Marcus J. Hines, Xue-Song Zhang, Anne Müller, Sergei B. Koralov, Martin J. Blaser |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
iScience, Vol 26, Iss 6, Pp 106810- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2589-0042 |
| DOI: |
10.1016/j.isci.2023.106810 |
| Popis: |
Summary: During postnatal development, both the maturing microbiome and the host immune system are susceptible to environmental perturbations such as antibiotic use. The impact of timing in which antibiotic exposure occurs was investigated by treating mice from days 5–9 with amoxicillin or azithromycin, two of the most commonly prescribed medications in children. Both early-life antibiotic regimens disrupted Peyer’s patch development and immune cell abundance, with a sustained decrease in germinal center formation and diminished intestinal immunoglobulin A (IgA) production. These effects were less pronounced in adult mice. Through comparative analysis of microbial taxa, Bifidobacterium longum abundance was found to be associated with germinal center frequency. When re-introduced to antibiotic-exposed mice, B. longum partially rescued the immunological deficits. These findings suggest that early-life antibiotic use affects the development of intestinal IgA-producing B cell functions and that probiotic strains could be used to restore normal development after antibiotic exposure. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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