| Autor: |
Catherine Okoukoni, PhD, Emory R. McTyre, MD, Diandra N. Ayala Peacock, MD, Ann M. Peiffer, PhD, Roy Strowd, MD, Christina Cramer, MD, William H. Hinson, PhD, Steve Rapp, PhD, Linda Metheny-Barlow, PhD, Edward G. Shaw, MD, MA, Michael D. Chan, MD |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Advances in Radiation Oncology, Vol 2, Iss 4, Pp 624-629 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2452-1094 |
| DOI: |
10.1016/j.adro.2017.08.013 |
| Popis: |
Purpose: Radiation-induced cognitive decline is relatively common after treatment for primary and metastatic brain tumors; however, identifying dosimetric parameters that are predictive of radiation-induced cognitive decline is difficult due to the heterogeneity of patient characteristics. The memory function is especially susceptible to radiation effects after treatment. The objective of this study is to correlate volumetric radiation doses received by critical neuroanatomic structures to post–radiation therapy (RT) memory impairment. Methods and materials: Between 2008 and 2011, 53 patients with primary brain malignancies were treated with conventionally fractionated RT in prospectively accrued clinical trials performed at our institution. Dose-volume histogram analysis was performed for the hippocampus, parahippocampus, amygdala, and fusiform gyrus. Hopkins Verbal Learning Test-Revised scores were obtained at least 6 months after RT. Impairment was defined as an immediate recall score ≤15. For each anatomic region, serial regression was performed to correlate volume receiving a given dose (VD(Gy)) with memory impairment. Results: Hippocampal V53.4Gy to V60.9Gy significantly predicted post-RT memory impairment (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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