| Autor: |
Stéphane Bretagne, Karine Sitbon, Françoise Botterel, Sarah Dellière, Valérie Letscher-Bru, Taieb Chouaki, Anne-Pauline Bellanger, Christine Bonnal, Arnault Fekkar, Florence Persat, Damien Costa, Nathalie Bourgeois, Frédéric Dalle, Florian Lussac-Sorton, André Paugam, Sophie Cassaing, Lilia Hasseine, Antoine Huguenin, Nadia Guennouni, Edith Mazars, Solène Le Gal, Milène Sasso, Sophie Brun, Lucile Cadot, Carole Cassagne, Estelle Cateau, Jean-Pierre Gangneux, Maxime Moniot, Anne-Laure Roux, Céline Tournus, Nicole Desbois-Nogard, Alain Le Coustumier, Olivier Moquet, Alexandre Alanio, Françoise Dromer |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Microbiology Spectrum, Vol 9, Iss 2 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2165-0497 |
| DOI: |
10.1128/Spectrum.01138-21 |
| Popis: |
ABSTRACT The aim of this study was to evaluate diagnostic means, host factors, delay of occurrence, and outcome of patients with COVID-19 pneumonia and fungal coinfections in the intensive care unit (ICU). From 1 February to 31 May 2020, we anonymously recorded COVID-19-associated pulmonary aspergillosis (CAPA), fungemia (CA-fungemia), and pneumocystosis (CA-PCP) from 36 centers, including results on fungal biomarkers in respiratory specimens and serum. We collected data from 154 episodes of CAPA, 81 of CA-fungemia, 17 of CA-PCP, and 5 of other mold infections from 244 patients (male/female [M/F] ratio = 3.5; mean age, 64.7 ± 10.8 years). CA-PCP occurred first after ICU admission (median, 1 day; interquartile range [IQR], 0 to 3 days), followed by CAPA (9 days; IQR, 5 to 13 days), and then CA-fungemia (16 days; IQR, 12 to 23 days) (P < 10−4). For CAPA, the presence of several mycological criteria was associated with death (P < 10−4). Serum galactomannan was rarely positive ( |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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