Cows with diverging haplotypes show differences in differential milk cell count, milk parameters and vaginal temperature after S. aureus challenge but not after E. coli challenge

Autor: Katharina Müller-Langhans, Lisa Oberberger, Yury Zablotski, Susanne Engelmann, Martina Hoedemaker, Christa Kühn, Hans-Joachim Schuberth, Holm Zerbe, Wolfram Petzl, Marie Margarete Meyerholz-Wohllebe
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMC Veterinary Research, Vol 20, Iss 1, Pp 1-16 (2024)
Druh dokumentu: article
ISSN: 1746-6148
DOI: 10.1186/s12917-024-03996-y
Popis: Abstract Background In dairy cattle, mastitis causes high financial losses and impairs animal well-being. Genetic selection is used to breed cows with reduced mastitis susceptibility. Techniques such as milk cell flow cytometry may improve early mastitis diagnosis. In a highly standardized in vivo infection model, 36 half-sib cows were selected for divergent paternal Bos taurus chromosome 18 haplotypes (Q vs. q) and challenged with Escherichia coli for 24 h or Staphylococcus aureus for 96 h, after which the samples were analyzed at 12 h intervals. Vaginal temperature (VT) was recorded every three minutes. The objective of this study was to compare the differential milk cell count (DMCC), milk parameters (fat %, protein %, lactose %, pH) and VT between favorable (Q) and unfavorable (q) haplotype cows using Bayesian models to evaluate their potential as improved early indicators of differential susceptibility to mastitis. Results After S. aureus challenge, compared to the Q half-sibship cows, the milk of the q cows exhibited higher PMN levels according to the DMCC (24 h, p
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