| Autor: |
Jason P. Li, MD, Charles Slocum, MD, John Sbarbaro, BA, Mark Schoenike, BS, Joseph Campain, BS, Cheshta Prasad, BA, Matthew G. Nayor, MD, MPH, Gregory D. Lewis, MD, Rajeev Malhotra, MD, MS |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
JACC: Advances, Vol 3, Iss 8, Pp 101101- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2772-963X |
| DOI: |
10.1016/j.jacadv.2024.101101 |
| Popis: |
Background: Peak oxygen consumption and oxygen pulse along with their respective percent predicted measures are gold standards of exercise capacity. To date, no studies have investigated the relationship between percent predicted peak oxygen pulse (%PredO2P) and ventricular-vascular response (VVR) and the association of %PredO2P with all-cause mortality in heart failure with preserved ejection fraction (HFpEF) patients. Objectives: The authors investigated the association between: 1) CPET measures of %PredO2P and VVR; and 2) %PredO2P and all-cause mortality in HFpEF patients. Methods: Our cohort of 154 HFpEF patients underwent invasive CPET and were grouped into %PredO2P tertiles. The association between percent predicted Fick components and markers of VVR (ie, proportionate pulse pressure, effective arterial elastance) was determined with correlation analysis. The Cox proportional hazards model was used to identify predictors of mortality. Results: The participants’ mean age was 57 ± 15 years. Higher %PredO2P correlated with higher exercise capacity. In terms of VVR, higher %PredO2P correlated with a lower pressure for a given preload (effective arterial elastance r = −0.45, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
