| Autor: |
Han Zhang, Rahul Kalla, Jie Chen, Jianhui Zhao, Xuan Zhou, Alex Adams, Alexandra Noble, Nicholas T. Ventham, Judith Wellens, Gwo-Tzer Ho, Malcolm G. Dunlop, Jan Krzysztof Nowak, Yuan Ding, Zhanju Liu, Jack Satsangi, Evropi Theodoratou, Xue Li |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-024-44841-y |
| Popis: |
Abstract This work aims to investigate how smoking exerts effect on the development of inflammatory bowel disease (IBD). A prospective cohort study and a Mendelian randomization study are first conducted to evaluate the association between smoking behaviors, smoking-related DNA methylation and the risks of Crohn’s disease (CD) and ulcerative colitis (UC). We then perform both genome-wide methylation analysis and co-localization analysis to validate the observed associations. Compared to never smoking, current and previous smoking habits are associated with increased CD (P = 7.09 × 10−10) and UC (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full text from SpringerLink