Determination of prilocaine HCl in bulk drug and pharmaceutical formulation by GC-NPD method
| Autor: | Atila Alptug, Kadioglu Yucel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Chemical Industry and Chemical Engineering Quarterly, Vol 19, Iss 2, Pp 313-319 (2013) |
| Druh dokumentu: | article |
| ISSN: | 1451-9372 2217-7434 |
| DOI: | 10.2298/CICEQ120124064A |
| Popis: | The novel analytical method was developed and validated for determination of prilocaine HCl in bulk drug and pharmaceutical formulation by gas chromatography-nitrogen phosphorus detection (GC-NPD). The chromatographic separation was performed using a HP-5MS column. The calibration curve was linear over the concentration range of 40-1000 ng ml-1 with a correlation coefficient of 0.9998. The limits of detection (LOD) and quantification (LOQ) of method were 10 ng ml-1 and 35 ng ml-1, respectively. The within-day and between-day precision, expressed as the percent relative standard deviation (RSD%) was less than 5.0%, and accuracy (percent relative error) was better than 4.0%. The developed method can be directly and easily applied for determination of prilocaine HCl in bulk drug and pharmaceutical formulation using internal standard methodology. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|