Determination of prilocaine HCl in bulk drug and pharmaceutical formulation by GC-NPD method
Autor: | Atila Alptug, Kadioglu Yucel |
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Jazyk: | angličtina |
Rok vydání: | 2013 |
Předmět: | |
Zdroj: | Chemical Industry and Chemical Engineering Quarterly, Vol 19, Iss 2, Pp 313-319 (2013) |
Druh dokumentu: | article |
ISSN: | 1451-9372 2217-7434 |
DOI: | 10.2298/CICEQ120124064A |
Popis: | The novel analytical method was developed and validated for determination of prilocaine HCl in bulk drug and pharmaceutical formulation by gas chromatography-nitrogen phosphorus detection (GC-NPD). The chromatographic separation was performed using a HP-5MS column. The calibration curve was linear over the concentration range of 40-1000 ng ml-1 with a correlation coefficient of 0.9998. The limits of detection (LOD) and quantification (LOQ) of method were 10 ng ml-1 and 35 ng ml-1, respectively. The within-day and between-day precision, expressed as the percent relative standard deviation (RSD%) was less than 5.0%, and accuracy (percent relative error) was better than 4.0%. The developed method can be directly and easily applied for determination of prilocaine HCl in bulk drug and pharmaceutical formulation using internal standard methodology. |
Databáze: | Directory of Open Access Journals |
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