| Autor: |
Yun-Jeong Choe, Jin Young Min, Hyunseong Lee, Sang-Yeop Lee, Joseph Kwon, Hye-Jin Kim, Jangho Lee, Hyun Min Kim, Hye Sun Park, Mi Young Cho, Ju-Yong Hyun, Hye Min Kim, Yong-Ho Chung, Sang Keun Ha, Hye Gwang Jeong, Inpyo Choi, Tae-Don Kim, Kwan Soo Hong, Eun Hee Han |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
iScience, Vol 25, Iss 9, Pp 105017- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2589-0042 |
| DOI: |
10.1016/j.isci.2022.105017 |
| Popis: |
Summary: The heterotypic CIC structures formed of cancer and immune cells have been observed in tumor tissues. We aimed to assess the feasibility of using heterotypic CICs as a functional biomarker to predict NK susceptibility and drug resistance. The heterotypic CIC-forming cancer cells showed a lower response to NK cytotoxicity and higher proliferative ability than non-CIC cancer cells. After treatment with anticancer drugs, cancer cells that formed heterotypic CICs showed a higher resistance to anticancer drugs than non-CIC cancer cells. We also observed the formation of more CIC structures in cancer cells treated with anticancer drugs than in the non-treated group. Our results confirm the association between heterotypic CIC structures and anticancer drug resistance in CICs formed from NK and cancer cells. These results suggest a mechanism underlying immune evasion in heterotypic CIC cancer cells and provide insights into the anticancer drug resistance of cancer cells. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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