| Autor: |
Albert Teis, G. Cediel, N. Amigó, J. Julve, J. Aranyó, J. Andrés-Cordón, C. Puig-Jové, E. Castelblanco, F. Gual-Capllonch, E. Ferrer-Sistach, N. Vallejo, G. Juncà, J. López-Ayerbe, M. De Antonio, M. Domingo, E. Santiago-Vacas, P. Codina, D. Mauricio, J. Lupón, Nuria Alonso, A. Bayes-Genis |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-021-82861-6 |
| Popis: |
Abstract Evidence regarding any association of HDL-particle (HDL-P) derangements and HDL-cholesterol content with cardiovascular (CV) death in chronic heart failure (HF) is lacking. To investigate the prognostic value of HDL-P size (HDL-Sz) and the number of cholesterol molecules per HDL-P for CV death in HF patients. Outpatient chronic HF patients were enrolled. Baseline HDL-P number, subfractions and HDL-Sz were measured using 1H-NMR spectroscopy. The HDL-C/P ratio was calculated as HDL-cholesterol over HDL-P. Endpoint was CV death, with non-CV death as the competing event. 422 patients were included and followed-up during a median of 4.1 (0–8) years. CV death occurred in 120 (30.5%) patients. Mean HDL-Sz was higher in CV dead as compared with survivors (8.39 nm vs. 8.31 nm, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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