Incidence of adverse reactions to COVID-19 vaccination: A meta-analysis of randomized controlled trials
| Autor: | Xin-Xin Wu, Jin-Jian Yao, Jin Qian, Qi-Feng Huang, Tang Deng, Shuang-Qin Xu, Hang-Fei Wang, Qi Li, Ji-Chao Peng, Yang Yi, Nan Li, Yue Huang, Xiao-Ran Liu |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Acute Disease, Vol 11, Iss 1, Pp 1-11 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2221-6189 2589-5516 |
| DOI: | 10.4103/2221-6189.336575 |
| Popis: | Objective: To systematically evaluate the incidence of adverse reactions to coronavirus disease 2019 (COVID-19) vaccination. Methods: We systematically searched PubMed, Embase, The Cochrane Library, Web of Science, CNKI, WanFang Data, and VIP Database from the inception of each database to August 31, 2021. Randomized controlled clinical trials (RCTs) on the safety of different types of COVID-19 vaccines were retrieved and analyzed. A random or fixed-effects model was used with an odds ratio as the effect size. The quality of each reference was evaluated. The incidence of the adverse reactions of the placebo group and the vaccination group was compared. Heterogeneity and publication bias were taken care of by meta-regression and sub-group analyses. Results: A total of 13 articles were included, with 81 287 subjects. Compared with the placebo group, the vaccination group showed a higher combined risk ratio (RR) of total adverse reactions (RR=1.67, 95% CI: 1.46-1.91, P |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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