Sub-acute toxicity evaluation of aqueous leaf extract from Passiflora edulis Sims f. edulis (Gulupa) in Wistar rats
| Autor: | Alex Rodríguez-Usaquén, Jhon Jairo Sutachan, Wilson Villarreal, Geison M Costa, Edward Javier Acero Mondragon, Ricardo Ballesteros-Ramírez, Sonia Luz Albarracín |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Toxicology Reports, Vol 11, Iss , Pp 396-404 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2214-7500 04937260 |
| DOI: | 10.1016/j.toxrep.2023.10.013 |
| Popis: | The genus Passiflora (Passifloraceae) comprises about 500 species. The Passiflora edulis stands out because of its economic and medicinal importance. It is widely planted in tropical and subtropical regions worldwide, especially in South America, the Caribbean, South Africa, and Asia. The aqueous extract of Passiflora edulis Sims f. edulis (Gulupa) leaves is used in traditional medicine for its soothing and tranquilizing effects on the central nervous system. Therefore, evaluating its safety for human use is a fundamental requirement to continue the development of new therapies within the framework of regulatory, preclinical, and clinical guidelines. Here, the sub-acute toxicity study was conducted following the Organization for Economic Cooperation and Development (OECD) guideline 407 for 28 days in Wistar albino rats. The study showed that 1000 mg/kg/day of the aqueous extract in 10 adult Wistar rats (five males and five females) was well tolerated. The hematological results are at normal levels. However, monocytopenia and eosinopenia were observed with a significant difference (P |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|