Anesthetic drugs modulate feeding behavior and hypothalamic expression of the POMC polypeptide precursor and the NPY neuropeptide

Autor:	E. Besnier, T. Clavier, M. C. Tonon, G. Pelletier, B. Dureuil, H. Castel, V. Compère
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Anesthetics Feeding behavior Neuropeptide Y Pro-opiomelanocortin Arcuate nucleus Anesthesiology RD78.3-87.3
Zdroj:	BMC Anesthesiology, Vol 18, Iss 1, Pp 1-7 (2018)
Druh dokumentu:	article
ISSN:	1471-2253
DOI:	10.1186/s12871-018-0557-x
Popis:	Abstract Background Several hypnotic drugs have been previously identified as modulators of food intake, but exact mechanisms remain unknown. Feeding behavior implicates several neuronal populations in the hypothalamic arcuate nucleus including orexigenic neuropeptide Y and anorexigenic pro-opiomelanocortin producing neurons. The aim of this study was to investigate in mice the impact of different hypnotic drugs on food consumption and neuropeptide Y or pro-opiomelanocortine mRNA expression level in the hypothalamic arcuate nucleus. Methods Saline control, isoflurane, thiopental, midazolam or propofol were administered to C57Bl/6 mice. Feeding behavior was evaluated during 6 h. In situ hybridization of neuropeptide Y and pro-opiomelanocortine mRNAs in the hypothalamus brain region was also performed. Data were analyzed by Kruskal Wallis test and analysis of variance (p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/04913b7a571b4ef79003b775bf49b7e0 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.