Interferon-γ Stimulates Monocyte Chemotactic Protein-1 Expression by Monocytes

Autor: J. M. Liebler, S. L. Kunkel, R. M. Allen, M. D. Burdick, R. M. Strieter
Jazyk: angličtina
Rok vydání: 1994
Předmět:
Zdroj: Mediators of Inflammation, Vol 3, Iss 1, Pp 27-31 (1994)
Druh dokumentu: article
ISSN: 0962-9351
1466-1861
09629351
DOI: 10.1155/S0962935194000050
Popis: Monocyte chemotactic protein (MCP-1) is a specific monocyte chemoattractant and activating factor produced by both immune cells (mononuclear phagocytes and lymphocytes) and non-immune cells (parenchymal and stromal cells). In order to define the conditions under which human monocytes express MCP-1, monocytes were exposed to IFN-γ, IL- lβ, TNF-α, IL-4 or PHA under serum free conditions. There was no significant MCP-1 production by monocytes following exposure to IL-lβ, TNF-α or IL-4. In contrast, stimulation with IFN-γ resulted in a dose dependent increase in MCP-1 protein and mRNA expression. Simultaneous stimulation with IFN-γ and IL-1β or TNF-α resulted in no further increase in MCP-1 production. It is concluded that IFN-γ, primarily a product of TH1 T lymphocytes, stimulates the expression of MCP-1 by monocytes.
Databáze: Directory of Open Access Journals
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