Circulating SMRP and CA‐125 before and after pleurectomy decortication for pleural mesothelioma

Autor:	Juuso Paajanen, Ahmed Sadek, William G. Richards, Yue Xie, Emanuele Mazzola, Kristina Sidopoulos, John Kuckelman, Ritu R. Gill, Raphael Bueno
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	biomarkers CA‐125 pleural mesothelioma pleurectomy decortication SMRP Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Thoracic Cancer, Vol 15, Iss 15, Pp 1237-1245 (2024)
Druh dokumentu:	article
ISSN:	1759-7714 1759-7706
DOI:	10.1111/1759-7714.15264
Popis:	Abstract Background Tumor recurrence remains the main barrier to survival after surgery for pleural mesothelioma (PM). Soluble mesothelin‐related protein (SMRP) and cancer antigen 125 (CA‐125) are established blood‐based biomarkers for monitoring PM. We prospectively studied the utility of these biomarkers after pleurectomy decortication (PD). Methods Patients who underwent PD and achieved complete macroscopic resection with available preoperative SMRP levels were included. Tumor marker levels were determined within 60 days of three timepoints: (1) preoperation, (2) post‐operation, and (3) recurrence. Results Of 356 evaluable patients, 276 (78%) had recurrence by the end of follow‐up interval. Elevated preoperative SMRP levels were associated with epithelioid histology (p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/048118174d574e8da1b2b95a600ba0d1 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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