| Autor: |
Zi-Dong Qiu, Xu-Ya Wei, Rui-Qi Sun, Jin-Long Chen, Ting Tan, Jia-Quan Xu, Guang-Hong Cui, Tong Chen, Juan Guo, Chang-Jiang-Sheng Lai, Lu-Qi Huang |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1511-1520 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2211-3835 |
| DOI: |
10.1016/j.apsb.2019.12.009 |
| Popis: |
Development of rapid analytical methods and establishment of toxic component limitation standards are of great importance in quality control of traditional Chinese medicine. Herein, an on-line extraction electrospray ionization mass spectrometry (oEESI-MS) coupled with a novel whole process integral quantification strategy was developed and applied to direct determination of nine key aconitine-type alkaloids in 20 Aconitum proprietary Chinese medicines (APCMs). Multi-type dosage forms (e.g., tablets, capsules, pills, granules, and liquid preparation) of APCM could be determined directly with excellent versatility. The strategy has the characteristics of high throughput, good tolerance of matrix interference, small amount of sample (∼0.5 mg) and reagent (∼240 μL) consumption, and short analysis time for single sample ( |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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