| Autor: |
Karin Wildi, Samantha Livingstone, Carmen Ainola, Sebastiano Maria Colombo, Silver Heinsar, Noriko Sato, Kei Sato, Mahé Bouquet, Emily Wilson, Gabriella Abbate, Margaret Passmore, Kieran Hyslop, Keibun Liu, Xiaomeng Wang, Chiara Palmieri, Louise E. See Hoe, Jae-Seung Jung, Katrina Ki, Christian Mueller, John Laffey, Paolo Pelosi, Gianluigi Li Bassi, Jacky Suen, John Fraser |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-023-45081-8 |
| Popis: |
Abstract Whilst the presence of 2 subphenotypes among the heterogenous Acute Respiratory Distress Syndrome (ARDS) population is becoming clinically accepted, subphenotype-specific treatment efficacy has yet to be prospectively tested. We investigated anti-inflammatory treatment in different ARDS models in sheep, previously shown similarities to human ARDS subphenotypes, in a preclinical, randomized, blinded study. Thirty anesthetized sheep were studied up to 48 h and randomized into: (a) OA: oleic acid (n = 15) and (b) OA-LPS: oleic acid and subsequent lipopolysaccharide (n = 15) to achieve a PaO2/FiO2 ratio of |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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