| Autor: |
Jennifer L. Hope, Christopher J. Stairiker, Panagiota I. Spantidea, Donald T. Gracias, Alison J. Carey, Adam J. Fike, Marjan van Meurs, Inge Brouwers-Haspels, Laurine C. Rijsbergen, Joseph A. Fraietta, Yvonne M. Mueller, Rosemarieke C. Klop, Erietta Stelekati, E. John Wherry, Stefan J. Erkeland, Peter D. Katsikis |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Frontiers in Immunology, Vol 8 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
1664-3224 |
| DOI: |
10.3389/fimmu.2017.01696 |
| Popis: |
We report here that the expression of the transcription factor T-bet, which is known to be required for effector cytotoxic CD8+ T lymphocytes (CTL) generation and effector memory cell formation, is regulated in CTL by microRNA-155 (miR-155). Importantly, we show that the proliferative effect of miR-155 on CD8+ T cells is mediated by T-bet. T-bet levels in CTL were controlled in vivo by miR-155 via SH2 (Src homology 2)-containing inositol phosphatase-1 (SHIP-1), a known direct target of miR-155, and SHIP-1 directly downregulated T-bet. Our studies reveal an important and unexpected signaling axis between miR-155, T-bet, and SHIP-1 in in vivo CTL responses and suggest an important signaling module that regulates effector CTL immunity. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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