| Autor: |
Ibai Diez, Carla Troyas, Corinna M. Bauer, Jorge Sepulcre, Lotfi B. Merabet |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
NeuroImage: Clinical, Vol 44, Iss , Pp 103688- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2213-1582 |
| DOI: |
10.1016/j.nicl.2024.103688 |
| Popis: |
Growing evidence suggests that cerebral connectivity changes its network organization by altering modular topology in response to developmental and environmental experience. However, changes in cerebral connectivity associated with visual impairment due to early neurological injury are still not fully understood. Cerebral visual impairment (CVI) is a brain-based visual disorder associated with damage and maldevelopment of retrochiasmal pathways and areas implicated in visual processing. In this study, we used a multimodal imaging approach and connectomic analyses based on structural (voxel-based morphometry; VBM) and resting state functional connectivity (rsfc) to investigate differences in weighted degree and link-level connectivity in individuals with CVI compared to controls with neurotypical development. We found that participants with CVI showed significantly reduced grey matter volume within the primary visual cortex and intraparietal sulcus (IPS) compared to controls. Participants with CVI also exhibited marked reorganization characterized by increased integration of visual connectivity to somatosensory and multimodal integration areas (dorsal and ventral attention regions) and lower connectivity from visual to limbic and default mode networks. Link-level functional changes in CVI were also associated with key clinical outcomes related to visual function and development. These findings provide early insight into how visual impairment related to early brain injury distinctly reorganizes the functional network architecture of the human brain. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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