Amikacin: Area Under Curve for Once Daily Dose and Its Correlation with Plasma Concentration at Six Hours Post Infusion

Autor: Teera Kolladaruengkri, Kamol Udol, Kantima Sangsiriwut, Dujpratana Pisalsarakij, Surapol Suwanagool
Jazyk: angličtina
Rok vydání: 2003
Předmět:
Zdroj: Siriraj Medical Journal, Vol 55, Iss 3 (2003)
Druh dokumentu: article
ISSN: 2228-8082
Popis: Aminoglycosides are commonly used for gram-negative septicemia. Formerly, peak and trough plasma levels were the monitoring parameters for conventional dose which was every eight hours. At present the recommended dose is once daily and the recommended monitoring parameters are the area under concentration time curve and the six-hour (range 146-180) for the area under curve and 6.79 milligrams per liter (range 5.6-7.9) for the six-hour plasma concentration post-infusion. The correlation of the area under curve and the six-hour plasma concentration post-infusion was reported in a linear equation with significance.
Databáze: Directory of Open Access Journals