| Autor: |
Ming Yang, Yongming Wu, Yanmei Lu, Changyuan Liu, Jielin Sun, Ming Liao, Min Qin, Linjian Mo, Yong Gao, Zheng Lu, Chunlei Wu, Youjie Zhang, Haiying Zhang, Xue Qin, Yanling Hu, Shijun Zhang, Jianling Li, Min Dong, S Lilly Zheng, Jianfeng Xu, Xiaobo Yang, Aihua Tan, Zengnan Mo |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
PLoS ONE, Vol 7, Iss 10, p e47990 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0047990 |
| Popis: |
IgM provides a first line of defense during microbial infections. Serum IgM levels are detected routinely in clinical practice. And IgM is a genetically complex trait. We conducted a two-stage genome-wide association study (GWAS) to identify genetic variants affecting serum IgM levels in a Chinese population of 3495, including 1999 unrelated subjects in the first stage and 1496 independent individuals in the second stage. Our data show that a common single nucleotide polymorphism (SNP), rs11552708 located in the TNFSF13 gene was significantly associated with IgM levels (p = 5.00×10(-7) in first stage, p = 1.34×10(-3) in second stage, and p = 4.22×10(-9) when combined). Besides, smoking was identified to be associated with IgM levels in both stages (P0.05). It is suggested that TNFSF13 may be a susceptibility gene affecting serum IgM levels in Chinese male population. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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