CLINICAL AND PHARMACOLOGICAL PECULIARITIES OF CETIRIZINE USE FOR THE THERAPY OF ALLERGIC DISEASES IN CHILDREN

Autor: Yu. G. Levina, L. S. Namazova-Baranova, A. A. Alexeeva, E. A. Vishneva, K. E. Efendieva, A. Y. Tomilova
Jazyk: ruština
Rok vydání: 2014
Předmět:
Zdroj: Педиатрическая фармакология, Vol 11, Iss 3, Pp 20-26 (2014)
Druh dokumentu: article
ISSN: 1727-5776
2500-3089
DOI: 10.15690/pf.v11i3.1003
Popis: The review is dedicated to treatment of allergic diseases in children, particularly to the use of the 2nd generation antihistamine. It demonstrates that mediator histamine has the crucial role in pathophysiology of the allergic reaction. Antihistamines block histamine action aimed at H1 receptors by way of competitive inhibition. The 2nd generation antihistamines are the drugs of choice for the treatment of allergic diseases due to the absence of sedative effect. The review presents clinical and pharmacological description of the selective 2nd generation antihistamine cetirizine, efficacy and safety of which have been appraised in numerous long-term clinical studies in children with allergic rhinitis, urticaria and atopic dermatitis.
Databáze: Directory of Open Access Journals