Effects of repeated intra-silicone oil injections of methotrexate on proliferative vitreoretinopathy grade C: a multicenter randomized controlled trial

Autor: Ramin Nourinia, Sare Safi, Mehrad Mohammadpour, Hamid Riazi-Esfahani, Mohammad Reza Ansari Astaneh, Khalil Ghasemi Falavarjani, Alireza Ramezani, Saeed Karimi, Sahba Fekri, Nazanin Ebrahimiadib, Elias Khalili Pour, Homayoun Nikkhah, Nasser Shoeibi, Narges Hassanpoor, Maryam Hosseini, Mojtaba Abrishami, Fatemeh Abdi, Anoushiravan Rahimi, Mohammad Hossein Jabbarpoor Bonyadi, Siamak Moradian, Sina Khosravi Mirzaei, Hamid Safi, Pasha Anvari, Kaveh Fadakar, Masoud Mirghorbani, Niloufar Mohammadbagheri, Firouze Hatami, Bahareh Kheiri, Mehdi Yaseri, Zahra Khorrami, Hamid Ahmadieh
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-024-79708-1
Popis: Abstract In this randomized controlled trial, we assessed the effects of three consecutive intra-silicone oil (SO) injections of methotrexate (MTX) on the outcomes of surgery for proliferative vitreoretinopathy grade C (PVR-C). Seventy-four eyes of 74 patients with PVR-C were included. Of these, 37 eyes were assigned to the MTX group and 37 eyes to the control group. Fourteen patients failed to comply with the 6-month follow-up period. All eyes underwent vitrectomy and SO injection. In the MTX group, 250 µg MTX was injected into the SO after surgery and at weeks 3 and 6 postoperatively. The primary outcome was the retinal reattachment rate at 6 months. The secondary outcomes included limited PVR recurrence and adverse events. Retinal reattachment was achieved in 22 eyes (73.3%) in the MTX group and 23 eyes (76.7%) in the control group (difference: -3.4%, 95% CI: -25.2–18.5%). Limited PVR recurrence was observed in one eye (4.5%) in the MTX group versus nine eyes (39.1%) in the control group at 6 months (P = 0.01). No adverse effects were observed. Adjunctive treatment with three consecutive applications of intra-SO MTX did not reveal a significant effect on the retinal re-detachment rate but could statistically significantly reduce limited PVR recurrence. Trial registration: http//ClinicalTrials.gov NCT04482543, 22/07/2020.
Databáze: Directory of Open Access Journals
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