Real-world effectiveness of full and booster mRNA vaccination for coronavirus disease 2019 against disease severity during the delta- and omicron-dominant phases: A propensity score-matched cohort study using the nationwide registry data in Japan

Autor: Tetsuya Suzuki, Yusuke Asai, Shinya Tsuzuki, Hidetoshi Nomoto, Nobuaki Matsunaga, Eiichi N. Kodama, Kayoko Hayakawa, Norio Ohmagari
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Microbiology, Immunology and Infection, Vol 57, Iss 1, Pp 20-29 (2024)
Druh dokumentu: article
ISSN: 1684-1182
DOI: 10.1016/j.jmii.2023.12.002
Popis: Background: To date, few studies from the Asian region have reported the effectiveness of messenger ribonucleic acid coronavirus disease 2019 (COVID-19) vaccines against disease progression and death after hospitalization. Methods: We evaluated the data from the COVID-19 registry in Japan during the delta- and omicron-dominant phases. A propensity score-matched cohort study was conducted between the incompletely (0–1 dose) and fully (2 doses) vaccinated groups during the delta-dominant phase and among the incompletely, fully, and booster (3 doses) vaccinated groups during the omicron-dominant phase. Results: In the delta-dominant phase, 411 pairs were matched. The fully vaccinated group showed a significantly lower oxygen supplementation rate (24.1 % vs. 41.1 %, p
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