Histomorphometric Changes in the Vessel Wall at the Site of Amputation in Diabetic Patients—Do They Influence Healing of the Stump?

Autor: SVLG Naidu, S Sengupta
Jazyk: angličtina
Rok vydání: 2005
Předmět:
Zdroj: Journal of Orthopaedic Surgery, Vol 13 (2005)
Druh dokumentu: article
ISSN: 2309-4990
23094990
DOI: 10.1177/230949900501300102
Popis: Purpose. To predict healing of the stump by assessing the microscopic vascular changes at the amputation site. Methods. A cohort study was conducted on 39 patients, 18 of them had below-knee amputation (group A) and 21 had ray amputation of a single toe (group B). Biopsies were taken from the anterior and posterior tibial arteries and the venae comitantes of group A patients. For group B patients, biopsies of the digital artery and dorsal vein of the toe were taken. Results. In group A, 15 patients required no further amputation (group A1) and 3 underwent a further above-knee amputation (group A2). In group B, 16 required no further amputation (group B1) and 5 underwent a below-knee amputation (group B2). Lumen narrowing caused by intimal thickening of the arteries was significantly different between groups A1 and A2 (p
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