| Autor: |
Mana Najafzade, Haleh Bakhshandeh, Monireh Movahedi, Zahra Zamani |
| Jazyk: |
perština |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
مجله علوم پزشکی صدرا, Vol 12, Iss 3, Pp 300-307 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2322-4339 |
| DOI: |
10.30476/smsj.2024.98739.1416 |
| Popis: |
Introduction: In recent years, due to the spread of drug resistance in the Plasmodium parasite and the shortcomings of anti-malarial drugs, the use of liposome-based nanomedicines in treating malaria has garnered significant attention. This research studied the effect of liposomes containing the antimalarial compound Eosin B on the Plasmodium berghei parasite in murine malaria.Methods: Liposomes containing Eosin B were prepared using cholesterol in the presence of Eosin B via solvent evaporation. Eosin B, Eosin B liposome, drug solvent, drug-free liposomes, and control drugs were administered to infected mice. The percentage of parasite inhibitory activity was evaluated using Peter’s test. In the in vitro model, the Plasmodium falciparum parasite was first cultured, and the survival percentage of the parasite in each group was investigated using the parasite lactate dehydrogenase test.Results: In each test group, the percentage of parasitemia under the effect of the Eosin B liposome was lower than that of Eosin B alone, and the inhibition percentage was significantly higher (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
